Voltammetric determination of isoniazid using cyclic renewable mercury film silver based electrode

Un método voltamperométrico catódico basado en un electrodo de plata con película de mercurio cíclica renovable fue investigado para la determinación de isoniazida.

A new cathodic voltammetry method for the detn. of isoniazid based on the cyclic renewable mercury film silver based electrode (Hg (Ag) FE) is presented.  The effects of various factors such as: preconcn. potential and time, pulse height, step potential and supporting electrolyte compn. are optimized.  The calibration graph is linear from 5 nM up to 500 nM (68.55 μgL^-1).  For Hg (Ag) FE with a surface area of 9.7 mm² without time consuming preconcn. the limits of detection LOD and quantification LOQ were 4.1 nM and 10.5 nM of isoniazid, resp.  The repeatability of the method at a concn. level of the analyte as low as 0.5 nM, expressed as RSD is 3.6% (n = 6).  The proposed method was successfully applied in anal. of isoniazid in simple and composed pharmaceutical formulations.

• Szlosarczyk, Marek; Piech, Robert; Bator, Beata Paczosa; Maslanka, Anna; Opoka, Wlodzimierz; Krzek, Jan
• Pharmaceutica Analytica Acta (2012), 3(9), 1000189/1-1000189/5.