Novel nanostructured electrochemical sensor for voltammetric determination of N-acetylcysteine in the presence of high concentrations of tryptophan

La voltamperometría de onda cuadrada utilizada como un novedoso sensor electroquímico de nanoestructura (electrodo de pasta de carbono químicamente modificado con nanotubos de multiparedes), ha resultado útil en la determinación de N-acetilcisteína en muestras de orina y drogas.

• A carbon paste electrode chem. modified with multiwall nanotubes and ethynylferrocene (ETFc) was used as a selective and sensitive electrochem. sensor for the detn. of minor amts. of N-acetylcysteine (N-AC) in the presence of a high concn. of tryptophan (Trp).  Square wave voltammetry (SWV) of N-AC at the modified electrode exhibited linear dynamic range with a detection limit (3 s) of 0.08 μmol L^-1.  The sepns. of anodic peak potentials of N-AC and Trp reached 400 mV using SWV.  With good selectivity and sensitivity, the present method provides a simple method for selective detection of N-AC in real samples such as drug and urine.
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• Fouladgar, Masoud; Karimi-Maleh, Hassan; Hosseinzadeh, Rahman
• Ionics (2013), 19(4), 665-672.