Electrochemical Behavior and Voltammetric Determination of Diclofenac at a Multi-Walled Carbon Nanotube-Ionic Liquid Composite Modified Carbon Ceramic Electrode

La determinación de diclofenaco se realiza por voltamperometría, mediante la superficie de un electrodo carboncerámico modificado con nanotubos de carbono de multipared y una composición líquida iónica.

This work describes the electrochem. behavior of diclofenac on the surface of a carbonceramic electrode (CCE) modified with multi-walled carbon nanotubes (MWCNT) and an ionic liq. (IL) composite.  The MWCNT-IL composite showed an enhancement effect in the electro-oxidn. of diclofenac with respect to a bare carbon ceramic electrode.  Based on the exptl. outcomes, a possible mechanism for the electro-oxidn. of diclofenac is proposed and discussed.  Under the optimized exptl. conditions, the MWCNT-ILCCE showed a linear response to diclofenac over the concn. range 50 nM-20 μM with a detection limit of 27 nM.  The developed diclofenac sensor showed good stability, sensitivity, and reproducibility in the measurement of diclofenac in human blood plasma samples.

• Razmi, Habib; Sarhang-Zadeh, Kianoush; Mohammad-Rezaei, Rahim
• Analytical Letters, Ahead of Print