Simultaneous Voltammetric Determination of Captopril and Hydrochlorothiazide on a Graphene/Ferrocene Composite Carbon Paste Electrode

El captopril y la hidroclorotiazida han sido determinadas simultáneamente a través de una voltamperometría de pulso diferencial con un electrodo de pasta de carbono compuesto de grafeno y ferroceno. Los dichos compuestos fueron hallados en muestras farmacéuticas y clínicas. 

In this work, a voltammetric method has been developed for the simultaneous detn. of captopril (CPT) and hydrochlorothiazide (HCT) in pharmaceutical combinations and clin. samples using a graphene/ferrocene composite carbon paste (GR/Fc/CP) electrode.  The electrochem. behaviors of CPT and HCT were individually and simultaneously investigated at the surface of the GR/Fc/CP electrode.  In differential pulse voltammetric (DPV) mode and under optimized exptl. conditions, CPT and HCT gave linear responses over the concn. ranges 1.0-430 μM and 0.5-390 μM (r²>0.99), resp.  The prepd. electrode could be used for simultaneous detn. of CPT and HCT in some real samples.

• Gholivand, Mohammad Bagher; Khodadadian, Mehdi
• From Electroanalysis, Ahead of Print