Iron(III) complexes of ethylenediamine derivatives of aminophenol ligands as models for enzyme-substrate adducts of catechol dioxygenases

En este trabajo se sintetizaron complejs de Fe (III) de de derivados de etilendiamina de ligandos aminofenol como modelos de enzima-sustrato aductos de dioxigenasa catecol. Se analizaron, entre otras técnicas, por voltamperometría cíclica.

 

In the present work, six N,N'-dimethylethylenediamine derivs. of substituted aminophenol ligands (H₂L^NEX, X: C, B, M, BM, Bu and OB) were synthesized by a convenient, green procedure.  The mentioned ligands were characterized by ¹H NMR and IR spectroscopies. iron complexes (FeL^NEX, X: C, B, M, BM, Bu and OB) of mentioned ligands, have been synthesized and characterized by IR, UV-Vis, elemental anal., single crystal X-ray diffraction, magnetic susceptibility studies and cyclic voltammetry techniques.  X-ray structure anal. has revealed that Fe(III) centers were surrounded by two phenolates, two amine nitrogens and two oxygen atoms of acetylacetonate ligand similar to the proposed catechol-bound intermediate for catechol dioxygenase.  The variable temp. magnetic susceptibility indicates paramagnetic iron(III) in monomer complexes.  All complexes undergo a metal-centered redn., and a ligand-centered oxidn.

Karimpour, Touraj; Safaei, Elham; Wojtczak, Andrzej; Jaglicic, Zvonko; Kozakiewicz, Anna                                 

Inorganica Chimica Acta (2013), 395, 124-134